Tryponil RTU (Code: DIT4-GE)
Tryponil RTU

Product name:

Tryponil RTU

Pharmaceutical form:
Transparent solution for parenteral use, changing from orange to red.

Quantitative and qualitative composition of 1 ml:
Diminazine aceturate .............................................................................................................. 70 mg.
Phenazone (antipyrine).................................................................................................. 375 mg.

Clinical pharmacology:
Diminazine aceturate belongs to the group of aromatic diamidines and is active against trypanosomiasis, babesiosis, theileriosis and mixed hemoprotozoal infections.

Indications:
Tryponil RTU is indicated for the treatment and prevention of trypanosomiasis, babesiosis, mixed hemoprotozoal infections and theileriosis in horses, cattle, buffaloes, sheep, goats and dogs.
1. Trypanosomiasis T congolense, T vivax , T. brucei and T. evansi;
2. Babesiosis B. bovis, B bigemina, B. ovis, B motasi, B. canis, B. equi and other Babesia spp.;
3. Mixed infections: infections caused by trypanosomes and different strains of Babesia.
4. Theileriosis Theileria annulata.
Tryponil RTU provides prophylactic protection against Asian (European) redwater fever (B. bovis) for 2 weeks and African redwater fever (B. bigemina) for 4 weeks. It can be used for short-term control in cases of sudden outbreaks of disease and high morbidity. Treatment of all affected animals and animals in contact with affected animals provides rapid but temporary relief.

Contraindications:
- Do not use in animals with a proven hypersensitivity to diminazine and/or phenazone;
- Do not use in animals with impaired renal and/or hepatic function;
- Do not use in camels.

Side effects:
After overdose or repeated administration, the following clinical signs may develop on the part of the central nervous system (salivation, sweating, tremor). In rare cases, multiple therapeutic doses may cause symptoms of severe nervous system irritation, pronounced hemorrhagic and malar lesions of the cerebellum and thalamus in cattle and dogs.
Multiple use of therapeutic doses may cause degenerative fatty changes in the liver, kidneys, myocardium and muscles.

Warnings and precautions:
- In dogs, the injection should be carried out only once and strictly according to body weight at the rate of 0.1 ml. per 2 kg. It is not allowed to exceed or repeat the prescribed dose;
- The use of Tryponil RTU provides prophylactic protection for 2-4 weeks, subject to the above conditions. Treatment of all cattle with Tryponil RTU within the next 24 hours is effective, unless the disease is in the terminal stage.
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Protection of animals from ticks reduces the risk of transmission of redwater fever. Therefore, control of cattle tick protection should also be linked to the vaccination process;
- If cattle are to be treated for redwater fever with Tryponil RTU, the animal should not be vaccinated against Asian (European) redwater fever for 1 month and against African redwater fever for 2 months after treatment. If Tryponil RTU was used to reduce the response to the redwater vaccine, it is necessary to revaccinate the treated animals. If immunity against Asian (European) redwater is required, revaccination is recommended after 1 month. If immunity against African redwater is required, revaccination is recommended after 2 months;
Avoid direct skin contact with the therapeutic solution. Wear protective gloves and clothing to prevent staining.
- Divide the total injection volume of the drug into two or more parts in cachectic and/or debilitated animals, and to ensure that insufficient doses are administered to the target animals, ensure proper calculation of body weight.
All empty containers and injection equipment should be disposed of in accordance with local regulations.
- Although this medicinal product has been extensively tested under various conditions, its effectiveness may be due to various reasons. If there is any doubt about the effectiveness of the medicinal product, please consult a veterinarian and inform the marketing authorisation holder.

Dosage:
For deep intramuscular injection:
The usual therapeutic dose is generally 1 ml per 20 kg body weight (3.5 mg/kg). Against T. Brucei, T. Evansi and Theileria annulata the indicated dose should be doubled (1 ml per 10 kg). Against resistant strains the dose may be increased to 8 mg/kg body weight (1 ml per 8.75 kg). The total dose, which is 4 g (57 ml) per animal, should not be exceeded. When administering large amounts of Tryponil RTU solution, it is advisable to divide the injection into several parts to avoid local reactions such as pain.

Withdrawal period:
- For meat: 20 days.
- For milk: 3 days.

Packaging:
100 ml type II glass bottle, closed with a bromobutyl stopper and an aluminum cap, placed in an individual cardboard box.

Storage conditions:
Tryponil RTU has a 2-year shelf life when stored in a dark and dry place at a temperature below 250C. After first opening the bottle, store at a temperature below 250C and use within the next two weeks.

Keep out of reach of children!

Pharmacotherapeutic group and ATC veterinary code:

Antiprotozoals, diminazines. ATC VET code: QP51DF01

Importer and exclusive distributor in Georgia “Invet” LLC Address:
Q. Tbilisi, Vakhushti Bagrationi 84a, Tel.: +995 32 2 25 19 66
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Manufacturer:

Interchemie werken “De Adelaar” B.V. Metaalweg 8, 5804 CG Venray, The Netherlands.