Veterinary drug "Colifloxi"
Annotation
Trade name
COLIFLOX
Drug form
Oral solution
Description
Yellow or yellowish transparent solution.
Composition
1 ml of the drug contains
Active substance: colistin sulfate 55 mg
Enrofloxacin 100 mg
Pharmacological group: Antibiotics
ATC vet code: QA07AA98
Pharmacological action
The active components (enrofloxacin, colistin sulfate) included in the composition of "Colifloxi" are characterized by a strong antibacterial effect against gram-positive and gram-negative microorganisms.
Enrofloxacin belongs to the group of fluoroquinolones and is characterized by a broad spectrum of antibacterial and antimycoplasmal activity. Inhibits the growth and development of gram-positive and gram-negative microorganisms. Enrofloxacin is quickly and well absorbed from the gastrointestinal tract and penetrates into all organs and tissues of the body. The maximum concentration in the blood is reached 1-2 hours after taking the drug and is maintained for 6 hours, and the therapeutic concentration lasts for 24 hours. Fluoroquinolones are mainly excreted unchanged in the urine and bile.
Colistin sulfate belongs to the polymyxin group of antibiotics. It has a bactericidal effect on gram-negative bacteria. Colistin sulfate binds to the phospholipids of the cytoplasmic membrane, increases the permeability of the cell membrane to both intracellular and extracellular components, disrupts metabolism and, as a result, lysis of the cells of microorganisms occurs.
When taken orally, colistin sulfate is practically not absorbed in the gastrointestinal tract, which creates a high antibacterial concentration of colistin in the intestine. It is almost completely excreted from the body with feces.
Indications
“Coliflox” is used to treat diseases of the gastrointestinal tract, respiratory system, urinary system caused by microorganisms sensitive to colistin sulfate and enrofloxacin in pigs and poultry;
Method of administration and dosage
“Coliflox” is administered to the target species orally with drinking water.
Pigs - 1 l of the drug is dissolved in 3000 l of drinking water, duration of treatment 3 - 5 days.
Poultry - 1 l of the drug is dissolved in 2000 l of drinking water, duration of treatment 3 - 5 days.
The drug is not used in laying birds and breeding animals.
A fresh aqueous solution of the drug should be prepared daily.
Contraindications
The drug "Coliflox" is not used
In case of hypersensitivity to enrofloxacin and/or colistin sulfate;
In case of severe kidney and/or liver diseases;
Incompatibility with other drugs
Not used in combination with tetracycline, chloramphenicol, macrolides and lincosamides.
Withdrawal period:
Meat - 9 days
Storage conditions
Store in a dry, dark place, out of reach of children, at room temperature
Release form
1000 ml oral solution placed in a polyethylene bottle closed with aluminum foil and a white screw cap
Shelf life
3 years.
Country of manufacture
Georgia
Manufacturing company
LLC "Davati"
St. Tbilisi, Gr. Khandzteli St. No. 10.
