Atacol

Davati, Georgia

Antibiotic suspension for oral administration

Composition:
Contains per ml: 
Colistin sulphate ............................................................................................................................ 2 400 000 IU. 

Description:
Colistin is an antibiotic from the group of polymyxins with bactericidal action against Gram-negative bacteria like E. coli, Haemophilus and Salmonella spp. Polymyxins interact strongly with phospholipids and penetrate into and disrupt the structure of cell membranes. They disorganise the outer membrane of Gram-negative bacteria by binding lipopolysaccharide (LPS, endotoxin) through direct interaction with the anionic lipid A region, thereby neutralising the endotoxin capacity of LPS. Colistin sulphate is poorly absorbed after oral administration, and serum concentrations are generally undetectable. In chickens, residues in serum were detectable for up to 6 hours after administration in the drinking water. Orally administered colistin is eliminated almost totally in faeces.

Indications:

Atacol  Oral is indicated for gastrointestinal infections caused by colistin sensitive micro-organisms like E. coli, Haemophilus and Salmonella spp. in calves, goats, sheep, poultry and swine.

Dosage:
For oral administration with drinking water: 
Calves, goats and sheep: ...................................................  Twice daily 1 ml per 40 kg body weight for 5 - 7 days. 
Poultry and swine: .....................................................1 litre per 2000 - 4000 litres of drinking water for 5 - 7 days.

Contra-indications:
Cases of hypersensitivity to colistin or to any of the excipients.  Administration to animals with seriously impaired renal functions or with an active microbial digestion.  Administration in subtherapeutic doses or in cases of resistance to colistin.

Withdrawal period:
Meat: 7 days.

Packaging:
Bottle containing 100 and 1000 ml.

Storage:  
Store in dark cool place between 20-25⁰ C temperature.