COLEXIL ORAL
Interchemie, Netherlands
Solution for oral administration
Product name: Colexil oral 1000 ml
Qualitative and quantitative composition per 1 ml:
Enrofloxacin................................................... .......... 100 mg/ml
Colistin Sulfate ................................................ .. 1 200 000 IU/ml
Pharmaceutical form:
Oral solution to be taken with drinking water.
Pharmacological properties:
The combination of colistin and enrofloxacin complement each other. Enrofloxacin is a synthetic, broad-spectrum antimicrobial substance that belongs to the group of fluoroquinoline antibiotics. Enrofloxacin acts on gram-negative and gram-positive bacteria and mycoplasma. It is well absorbed orally and rapidly excreted with bile and urine, mainly as enrofloxacin and ciprofloxacin metabolites. Colistin is an antibiotic of the polymyxin group, which has bactericidal activity against gram-negative bacteria, such as E. coli, Haemophilus spp. and Salmonella spp. It is poorly absorbed after oral administration, and its concentration in the serum of target animals is essentially undetectable. Colistin taken orally is almost completely excreted in the feces.
Target animals: pigs and poultry.
Indications:
Colexil Oral (Colexil Oral) is prescribed for gastrointestinal, respiratory and urinary tract infections caused by colistin- and enrofloxacin-susceptible microorganisms in pigs and poultry, such as Campylobacter spp., E. coli, Haemophilus spp., Mycoplasma spp., Pasteurella spp. and Salmonella spp..
Contraindications:
Cases of hypersensitivity to colistin and/or enrofloxacin or any of the excipients. It is not allowed to appoint in animals with serious impairment of kidney and/or liver function. Cases of resistance to quinolones and/or colistin. Do not use on egg-laying birds whose eggs are intended for human consumption. It is not allowed to prescribe to mace or lactating animals. It is not allowed to prescribe Colexil Oral (Colexil Oral) in the smallest therapeutic doses or for the purpose of prevention.
Adverse effect:
All quinolone antibiotics have the ability to cause joint damage in young animals. During the period of active growth, enrofloxacin can affect the cartilage of the joints. Digestive disorders such as intestinal dysbiosis, gas accumulation, mild diarrhea or vomiting may develop. Side effects of quinolones such as rash and central nervous system disorders are possible.
Special precautions for use: none.
Use during pregnancy and lactation:
It is not allowed to use Colexil Oral (Colexil Oral) in lactating or lactating animals.
Interactions:
No information on any interaction is found in the available literature. However, it is not recommended to mix Colexil Oral with other drugs.
Colexil Oral (Colexil Oral) 47 dosage recommendations and administration method(s):
For oral administration with drinking water.
Pig: 1 liter per 3000 liters of drinking water for 3-5 days.
Poultry: 1 liter per 2000 liters of drinking water for 3-5 days.
Only a sufficient amount of medicinal drinking water should be prepared according to daily needs. Medicinal drinking water should be changed every 24 hours.
Overdose:
A significant overdose may cause vomiting, loss of appetite or kidney failure.
Special Precautions: None.
Period of exit of the drug from the body:
Meat and offal: 9 days Not allowed for use on egg-laying birds whose eggs are intended for human consumption. Special precautions to be taken by the person handling the product: Due to possible sensitization and contact dermatitis, direct contact of the product with the skin should be avoided during use.
Incompatibility with other drugs:
no important information regarding incompatibility is known.
Storage conditions:
Colexil Oral has a shelf life of 3 years in a dark place at room temperature (15-25°C) under storage conditions. The use of drinking water mixed with Colexil Oral (Colexil Oral) is allowed for 24 hours if the room temperature (15-25°C) regime is observed. Special safety measures during storage: Colexil Oral should be stored in a dark place at room temperature (15-25 °C) in well-closed bottles. All opened and waste products must be disposed of in accordance with national or local regulations.
Packaging: 1000 ml polyethylene bottles.
Importer and exclusive distributor in Georgia:
"Invet LLC" address: St. Tbilisi, 84a Vakhushti Bagrationi str., tel.: +995 32 2 25 19 66;
Trade license holder:
Interchemie werken "De Adelaar" B.V. Metaalweg 8, 5804 CG Venray, The Netherlands
Manufacturer:
Interchemie werken "De Adelaar" B.V. Metaalweg 8, 5804 CG Venray, The Netherlands
