Veterinary medicinal product “Ciproflox”

Annotation

Trade name:
Ciproflox
CIPROFLOX

Dosage form:
Oral powder

Description:
White powder

Composition:
1 g of powder contains:
Active substances:

• Ciprofloxacin hydrochloride – 200 mg

• Amoxicillin trihydrate – 100 mg

Pharmacological group:
Antibacterial agent for systemic use
ATC vet code: QJ01

Pharmacological action:
Due to the synergistic effect of the active substances contained in Ciproflox, the activity of the preparation is significantly enhanced.

Amoxicillin belongs to the group of semi-synthetic penicillins with a broad spectrum of antimicrobial activity. It has a bactericidal effect against Gram-positive and Gram-negative bacteria such as Campylobacter, Escherichia coli, Erysipelothrix, Haemophilus, Pasteurella. Amoxicillin is effective against clostridia, corynebacteria, salmonellae, penicillin-resistant staphylococci and streptococci. Its bactericidal action is based on inhibition of bacterial cell wall synthesis.

Ciprofloxacin belongs to the fluoroquinolone group of synthetic antibiotics and is active against a wide range of Gram-negative and Gram-positive microorganisms, especially Escherichia coli, Corynebacterium pyogenes, Salmonella spp., Shigella spp., Pasteurella, Staphylococcus spp., Staphylococcus hyicus, Streptococcus spp., Klebsiella spp., Corynebacterium spp., Enterobacterium spp., Erysipelothrix rhusiopathiae, Proteus spp., Brucella canis, Actinobacillus spp., Listeria monocytogenes, Haemophilus spp., Clostridium spp.

The mechanism of action of ciprofloxacin is associated with inhibition of the enzyme topoisomerase II, which ensures DNA replication in the bacterial cell nucleus, leading to disruption of protein synthesis and death of the microorganism.

Pharmacokinetics:
After oral administration, the drug is rapidly and almost completely absorbed from the gastrointestinal tract. Maximum concentrations of the active substances in many tissues and biological fluids are reached within 1–2 hours. Therapeutic concentrations are maintained for 24 hours.

Indications

The drug is intended for the treatment of infections of the respiratory system, gastrointestinal tract, urogenital system, colibacillosis, salmonellosis, mycoplasmosis, staphylococcal and streptococcal infections in calves, pigs, and poultry.

Dosage and administration:

Ciproflox is administered orally to target species:

• Calves, pigs: 1 g of the product per 20 kg of body weight, twice daily for 5–7 days

• Poultry: 1 g of the product dissolved in 4 liters of drinking water, treatment duration 3–5 days

A fresh aqueous solution must be prepared daily.

Warning:

The product must not be used in laying hens.

Contraindications:

Do not use in case of hypersensitivity to ciprofloxacin or amoxicillin trihydrate, or in animals with impaired kidney or liver function.

Ciproflox should not be administered together with beta-lactam antibiotics, chloramphenicol, macrolides, or lincosamides.

Side effects:

If the recommended dosage regimen is violated, allergic reactions may occur.

Withdrawal period:

• Meat – 12 days (calves, pigs)

• Meat – 11 days (poultry)

Storage conditions:

Store in a dry place, protected from light, out of reach of children, at room temperature.

Form of release:

200 g oral powder in a white polyethylene container and 1 g oral powder in foil sachets.

Shelf life:

3 years

Country of manufacture:

Georgia

Manufacturer:

LLC “Davati”
10 Gr. Khandzteli St., Tbilisi, Georgia